Peer-Reviewed Publications

ORCID ID: 0000-0002-1211-9629

  1. Chiolerio P, Auletta B, Pezzini C, Sartore L, Gregolon G, Gagliano O, Laterza C, Valdez VRB, Cacchiarelli D, Luni C, Viscomi C, Planque M, Fendt SM, Sandri M, Sartori R, Urciuolo A. 2026. "Human neuromuscular organoids mimic cancer-induced muscle cachexia". Cell Rep Methods 6:101331. DOI: 10.1016/j.crmeth.2026.101331

  2. Jones BC, Benedetti G, Calà G, Amiri R, Tullie L, Lutman R, Sufi J, Holland L, Jafree DJ, Balys M, Anderson G, Simcock IC, Arthurs OJ, Eaton S, Elvassore N, Li VSW, Tape CJ, Jones KDJ, Luni C, Giobbe GG, De Coppi P. 2026. "Human gastric multi-regional assembloids for functional parietal maturation and patient-specific modelling of antral foveolar hyperplasia". Nat Biomed Eng. DOI: 10.1038/s41551-025-01553-y

  3. Mazzei A*, Martewicz S*, Amiri R, Cui M, Elvassore N, Luni C#. 2025. "Functional CRISPR-Cas9 knockout screening of the genetic determinants of human fibroblast migration propensity". Biotechnol Progr 42:e70076. DOI: 10.1002/btpr.70076

  4. Rastovic U, Campinoti S, Wei L, Almeida B, Bozzano SF, Amiri R, Harris N, Ajayi O, Koay TS, Kerins C, Kenny FN, Zamalloa A, Adofina L, Miquel R, Zen Y, Srinivasan P, Menon K, Heaton N, Luni C, Gentleman E, Shaw T, Ure D, Chokshi S, Urbani L, Palma E. 2025. "Comprehensive analysis of extracellular matrix remodelling via cyclophilin inhibition in human models of alcohol-related liver fibrosis". Br J Pharmacol 182:5647–5669. DOI: 10.1111/bph.70139

  5. Auletta B, Chiolerio P, Cecconi G, Rossi L, Sartore L, Cecchinato F, Barbato G, Lauroja A, Maghin E, Easler M, Raffa P, Angiolillo S, Qin W, Frison R, Calabrò S, Villa C, Gagliano O, Laterza C, Cacchiarelli D, Cescon M, Giomo M, Torrente Y, Luni C, Piccoli M, Elvassore N, Urciuolo A. 2025. "Tissue-engineered neuromuscular organoids". Commun Biol 8(1):1074. DOI: 10.1038/s42003-025-08484-z

  6. Pirozzi F*, Amiri R*, Luni C, Rossi A, Melis D, Fedele R, Rosano C, Strisciuglio P, Oosterveer MH, Derks TGJ, Parenti G, Caterino M, Ruoppolo M. 2025. "Multiomics approach provides insight into altered choline metabolism and liver injury in patients with Glycogen storage disease type Ia". Sci Rep-UK 15(1):20658. DOI: 10.1038/s41598-025-06272-7

  7. Loukogeorgakis SP, Michielin F, Al-Juffali N, Jimenez J, Shibuya S, Allen-Hyttinen J, Eastwood MP, Alhendi ASN, Davidson J, Naldi E, Maghsoudlou P, Tedeschi A, Khalaf S, Platé M, Fachin C, Dias ADS, Sindhwani N, Scaglioni D, Xenakis T, Sebire N, Giomo M, Eaton S, Toelen J, Luni C, Pavan P, Carmeliet P, Russo F, Janes S, Nikolic MZ, Elvassore N, Deprest J, De Coppi P. 2025. "Prenatal VEGF nano-delivery reverses congenital diaphragmatic hernia-associated pulmonary abnormalities". Am J Respir Crit Care Med 211(6):992-1006. DOI: 10.1164/rccm.202401-0161OC

  8. Michielin F, Urbani L, Luni C, Gagliano O. 2024. "Editorial: 3D-engineered organoids for modelling tissue development and precision medicine". Front Chem Eng (6). DOI: 10.3389/fceng.2024.1376921

  9. Panariello F*, Gagliano O*, Luni C*, Grimaldi A*, Angiolillo S, Qin W, Manfredi A, Annunziata P, Slovin S, Vaccaro L, Riccardo S, Bouche V, Dionisi M, Salvi M, Martewicz S, Hu M, Cui M, Stuart H, Laterza C, Baruzzo G, Schiebinger G, Di Camillo B, Cacchiarelli D, Elvassore N. 2023. "Cellular population dynamics shape the route to human pluripotency". Nat Commun 14:2829. DOI: 10.1038/s41467-023-37270-w

    Selected as Featured Article

  10. Luni C#, Urciuolo A#, Crook J#, Gentile C#. 2023."Editorial: New trends in biomimetic tissue and organ modelling". Front Med Technol (5). DOI: 10.3389/fmedt.2023.1182828

  11. Cesare E*, Urciuolo A*, Stuart HT*, Torchio E, Gesualdo A, Laterza C, Gagliano O, Martewicz S, Cui M, Manfredi A, Di Filippo L, Sabatelli P, Squarzoni S, Zorzan I, Betto RM, Martello G, Cacchiarelli D, Luni C, Elvassore N. 2022. "3D ECM-rich environment sustains the identity of naive human iPSCs". Cell Stem Cell 29(12):1703-1717.e7. DOI: 10.1016/j.stem.2022.11.011

  12. Martewicz S, Zhu X, Qu S, Cui M, Grespan E, Luni C, Jiang B, Yang G, Elvassore N. 2022. "Micropillar based phenotypic screening platform uncovers involvement of HDAC2 in nuclear deformability". Biomaterials 286:121564. DOI: 10.1016/j.biomaterials.2022.121564

  13. Rui X, Cui M, Martewicz S, Hu M, Gagliano O, Elvassore N, Luni C#. 2022. "Extracellular phosphoprotein regulation is affected by culture system scale-down". BBA-Gen Subjects 1866(8):130165. DOI: 10.1016/j.bbagen.2022.130165

  14. Luni C, Gagliano O, Elvassore N. 2022. "Derivation and differentiation of human pluripotent stem cells in microfluidic devices". Annu Rev Biomed Eng 24:231-248. DOI: 10.1146/annurev-bioeng-092021-042744

  15. Giobbe GG, Bonfante F, Jones BC, Gagliano O, Luni C, Zambaiti E, Perin S, Laterza C, Busslinger G, Stuart H, Pagliari M, Bortolami A, Mazzetto E, Manfredi A, Colantuono C, Di Filippo L, Pellegata A, Panzarin V, Thapar N, Li VSW, Eaton S, Cacchiarelli D, Clevers H, Elvassore N, De Coppi P. 2021. "SARS-CoV-2 infection and replication in human gastric organoids". Nat Commun 12:6610. DOI: 10.1038/s41467-021-26762-2

  16. Gagliano O, Luni C, Li Y, Angiolillo S, Qin W, Panariello F, Cacchiarelli D, Takahashi JS, Elvassore N. 2021. "Synchronization between peripheral circadian clock and feeding-fasting cycles in microfluidic device sustains oscillatory pattern of transcriptome". Nat Commun 12: 6185. DOI: 10.1038/s41467-021-26294-9

  17. Michielin F, Giobbe GG, Luni C, Hu Q, Maroni I, Orford MR, Manfredi A, Di Filippo L, David AL, Cacchiarelli D, De Coppi P, Eaton S, Elvassore N. 2020. "The microfluidic environment reveals a hidden role of self-organizing extracellular matrix in hepatic commitment and organoid formation of hiPSC". Cell Rep 33, 108453. DOI: 10.1016/j.celrep.2020.108453

  18. Martewicz S, Luni C, Zhu X, Cui M, Hu M, Qu S, Buratto D, Yang G, Grespan E, Elvassore N. 2020. "Nuclear morphological remodeling in human granulocytes is linked to prenylation independently from cytoskeleton". Cells-Basel 9:2509. DOI: 10.3390/cells9112509

  19. Raffa P*, Scattolini V*, Gerli MFM, Perin S, Cui M, De Coppi P, Elvassore N, Caccin P, Luni C, Urciuolo A. 2020. "Decellularized skeletal muscles display neurotrophic effects in three‐dimensional organotypic cultures". STEM CELLS Transl Med 1-11. DOI: 10.1002/sctm.20-0090

  20. Urciuolo A, Serena E, Ghua R, Zatti S, Giomo M, Mattei N, Vetralla M, Selmin G, Luni C, Vitulo N, Valle G, Vitiello L, Elvassore N. 2020. "Engineering a 3D in vitro model of human skeletal muscle at the single fiber scale". PLoS ONE 15(5):e0232081. DOI: 10.1371/journal.pone.0232081

  21. Giobbe GG*, Crowley C*, Luni C*, Campinoti S, Khedr M, Kretzschmar K, De Santis MM, Zambaiti E, Hu Q, Michielin F, Meran L, Urbani L, Manfredi A, van Son G, Eaton S, Cacchiarelli D, Li VSW, Clevers H, Bonfanti P, Elvassore N, De Coppi P. 2019. "Extracellular matrix hydrogel derived from decellularized tissues enables endoderm organoid culture". Nat Commun 10:5658. DOI: 10.1038/s41467-019-13605-4

    22. Top 50 most read Nature Communications articles in life and biological sciences published in 2019 (ranking 28th).

  22. Tonon F*, Giobbe GG*, Zambon A, Luni C, Gagliano O, Floreani A, Grassi G, Elvassore N. 2019. "In vitro metabolic zonation through oxygen gradient on a chip". Sci Rep 9(1):13557. DOI: 10.1038/s41598-019-49412-6

  23. Gagliano O*, Luni C*, Qin W, Bertin E, Torchio E, Galvanin S, Urciuolo A, Elvassore N. 2019. "Microfluidic reprogramming to pluripotency of human somatic cells". Nat Prot 14:722–737. DOI: 10.1038/s41596-018-0108-4

  24. Zoso A, Zambon A, Gagliano O, Giulitti S, Prevedello L, Fadini GP, Luni C, Elvassore N. 2019. "Cross-talk of healthy and impaired human tissues for dissection of disease pathogenesis". Biotechnol Progr 35:e2766. DOI: 10.1002/btpr.2766

  25. Beninatto R, Barbera C, De Lucchi O, Borsato G, Serena E, Guarise C, Pavan M, Luni C, Martewicz S, Galesso D, Elvassore N. 2019. "Photocrosslinked hydrogels from coumarin derivatives of hyaluronic acid for tissue engineering applications". Mater Sci Eng C Mater Biol Appl 96:625–634. DOI: 10.1016/j.msec.2018.11.052

  26. Martewicz S*, Luni C*, Serena E, Pavan P, Chen VH-S, Rampazzo A, Elvassore N. 2019. "Transcriptomic characterization of a human in vitro model of arrhythmogenic cardiomyopathy under topological and mechanical stimuli". Ann Biomed Eng. 47(3):852-865. DOI: 10.1007/s10439-018-02134-8

  27. Hu Q, Luni C, Elvassore N. 2018. "Microfluidics for secretome analysis under enhanced endogenous signaling". Biochem Bioph Res Co 497(2):480-484. DOI: 10.1016/j.bbrc.2018.02.025

  28. Scattolini V*, Luni C*, Zambon A, Galvanin S, Gagliano O, Ciubotaru CD, Avogaro A, Mammano F, Elvassore N, Fadini GP. 2016. "Simvastatin rapidly and reversibly inhibits insulin secretion in intact single-islet cultures". Diabetes Ther 7(4):679-693. DOI: 10.1007/s13300-016-0210-y

  29. Gagliano O, Elvassore N, Luni C#. 2016. "Microfluidic technology enhances the potential of human pluripotent stem cells". Biochem Bioph Res Co 473(3):683-687. DOI: 10.1016/j.bbrc.2015.12.058

  30. Luni C*, Giulitti S*, Serena E, Ferrari L, Zambon A, Gagliano O, Giobbe GG, Michielin F, Knöbel S, Bosio A, Elvassore N. 2016. "High-efficiency cellular reprogramming with microfluidics". Nat Methods 13(5):446-452. DOI: 10.1038/nmeth.3832

    31. Top cover
    Journal top cover.

  31. Giobbe GG, Michielin F, Luni C, Giulitti S, Martewicz S, Dupont S, Floreani A, Elvassore N. 2015. "Functional differentiation of human pluripotent stem cells on a chip". Nat Methods 12:637-640. DOI: 10.1038/nmeth.3411

  32. Lamberti F, Brigo L, Favaro M, Luni C, Zoso A, Cattelan M, Agnoli S, Brusatin G, Granozzi G, Giomo M, Elvassore N. 2014. "Optoelectrochemical biorecognition by optically transparent highly conductive graphene-modified fluorine-doped tin oxide substrates". ACS Appl Mater Interfaces 6(24):22769-77. DOI: 10.1021/am506941u

  33. Zambon A, Zoso A, Luni C, Frommer WB, Elvassore N. 2014. "Determination of glucose flux in live myoblasts by microfluidic nanosensing and mathematical modeling". Integr Biol 6(3):277-88. DOI: 10.1039/ C3IB40204E

    Selected as an Integrative Biology HOT Article

  34. Luni C, Serena E, Elvassore N. 2014. "Human-on-chip for therapy development and fundamental science". Curr Opin Biotech 25:45-50. DOI: 10.1016/j.copbio.2013.08.015

  35. Franzin C, Piccoli M, Serena E, Bertin E, Urbani L, Luni C, Pasqualetto V, Eaton S, Elvassore N, De Coppi P, Pozzobon M. 2013. "Single-cell PCR analysis of murine embryonic stem cells cultured on different substrates highlights heterogeneous expression of stem cell markers". Biol Cell 105(12):549-560. DOI: 10.1111/boc.201300034

  36. Luni C*, Michielin F*, Barzon L, Calabrò V, Elvassore N. 2013. "Stochastic model-assisted development of efficient low-dose viral transduction in microfluidics". Biophys J 104(4):934-942. DOI: 10.1016/j.bpj.2012.12.049

  37. Luni C, Marth JD, Doyle III FJ. 2012. "Computational modeling of glucose transport in pancreatic β-cells identifies metabolic thresholds and therapeutic targets in diabetes". PLoS ONE 7(12):e53130. DOI: 10.1371/journal.pone.0053130

  38. Lamberti F*, Luni C*, Zambon A, Serra PA, Giomo M, Elvassore N. 2012. "Flow biosensing and sampling in indirect electrochemical detection". Biomicrofluidics 6(2) pii: 024114. DOI: 10.1063/1.4705368

    Selected for the May 1, 2012 issue of Virtual Journal of Biological Physics Research

  39. Zatti S, Zoso A, Serena E, Luni C, Cimetta E, Elvassore N. 2012. "Micro-patterning topology on soft substrates affects myoblasts proliferation and differentiation". Langmuir 28(5):2718-2726. DOI: 10.1021/la204776e

  40. Luni C, Doyle III FJ. 2011. "Robust multi-drug therapy design and application to insulin resistance in type 2 diabetes". Int J Robust Nonlin 21(15):1730-1741. DOI: 10.1002/rnc.1756

  41. Luni C, Zagallo M, Albania L, Piccoli M, Pozzobon M, De Coppi P, Elvassore N. 2011. "Design of a stirred multi-well bioreactor for expansion of CD34+ umbilical cord blood cells in hypoxic conditions". Biotechnol Prog 27(4):1154-1162. DOI: 10.1002/btpr.582

  42. Luni C, Doyle III FJ, Elvassore N. 2011. "Cell population modeling describes intrinsic heterogeneity: hematopoietic stem cells, a case study". IET Syst Biol 5(3):164-173. DOI: 10.1049/iet-syb.2009.0059

    Awarded The IET Systems Biology Premium Award 2013

  43. Luni C, Shoemaker JE, Sanft KR, Petzold LR, Doyle III FJ. 2010. "Confidence from uncertainty - A multi-target drug screening method from robust control theory". BMC Syst Biol 4(1):161-171. DOI: 10.1186/1752-0509-4-161

  44. Luni C*, Feldman HC*, Pozzobon M, De Coppi P, Meinhart CD, Elvassore N. 2010. "Microliter-bioreactor array with buoyancy-driven stirring for human hematopoietic stem cell culture". Biomicrofluidics 4(3) pii: 034105. DOI: 10.1063/1.3380627

    Selected for the August 15, 2010 issue of Virtual Journal of Biological Physics Research

  45. Luni C, Sanft KR, Petzold LR, Doyle III FJ. 2010. "Modelling of detailed insulin receptor kinetics affects sensitivity and noise in the downstream signalling pathway". Proceedings of the 9th International Symposium on Dynamics and Control of Process Systems (DYCOPS 2010), Leuven, Belgium, July 5-7, 2010

  46. Flaibani M, Luni C, Sbalchiero E, Elvassore N. 2009. "Flow cytometric cell cycle analysis of muscle precursor cells cultured within 3D scaffolds in a perfusion bioreactor". Biotechnol Prog 25(1):286-295. DOI: 10.1002/btpr.40

  47. Zavan B, Vindigni V, Vezzù K, Zorzato G, Luni C, Abatangelo G, Elvassore N, Cortivo R. 2009. "Hyaluronan based porous nano-particles enriched with growth factors for the treatment of ulcers: a placebo-controlled study". J Mater Sci Mater Med 20(1):235-247. DOI: 10.1007/s10856-008-3566-3